Palm oil is one of the plantation crops in Indonesia that has a pretty bright future. Palm oil is a reliable export commodity in Indonesia, the domestic market share is quite large and the export market is always open. Oil palm plantations are faced with the presence of plant-disturbing organisms as a limiting factor. One of the plant pests that often interfere with oil palm cultivation is weeds. The presence of weeds can cause many losses including reducing the ability of production, polluting the quality of production, and disrupt the smooth work of farmers. This study aims to determine the effectiveness of IPA Glyphosate herbicide for controlling common weeds in oil palm plants. The study was conducted at PTPN VIII Sukamaju, Sukabumi Regency, Indonesia from June 2016 to September 2016 The experiment used an experimental method with a Randomized Block Design consisting of 7 treatments and 4 replications. The treatments consisted of IPA Glyphosate herbicide at a dose of 546.75 g/ha; 729 g/ha; 911.25 g/ha; 1093.5 g/ha; 1275.75 g/ha; weeding manually and Control. The results showed that the IPA Glyphosate herbicide dose 546.75-1275.75 g/ha was an effective herbicide in controlling broadleaf weeds such as Synedrella nodiflora, Ageratum conyzoides and Peperomia pellucida and grass weeds such as Setaria palmifolia in oil palm plantations. IPA Glyphosate herbicide dose 546.75-1275.75 g/ha until observation 3 weeks after application does not show symptoms of poisoning in oil palm plants.