Vol. 7, Issue 11, Part A (2025)

The present investigation was conducted to assess the effect of different levels of Saccharomyces cerevisiae supplementation on the blood biochemical profile of broiler chickens. A total of 120-day-old Cobb-400 chicks were randomly allotted to four dietary treatments: T₀ (control), T₁ (1.0% yeast), T₂ (1.5% yeast), and T₃ (2.0% yeast), each with five replicates of six birds. Blood samples were collected on the 21^st and 42^nd days of age for the estimation of serum metabolites and enzyme activities. The results revealed that dietary supplementation of yeast significantly (p<0.05) influenced lipid and protein metabolism. Birds in T₂ exhibited the lowest serum cholesterol, LDL, and triglyceride levels, and the highest HDL, total protein, and albumin concentrations. Liver enzyme activities (ALT, AST, ALP) were also reduced in T₂, indicating improved hepatic health. The findings suggest that inclusion of S. cerevisiae at 1.5% enhances serum lipid metabolism, protein synthesis, and liver function in broilers, thereby improving overall physiological performance.